منابع مشابه
Tissue penetration of antifungal agents.
Understanding the tissue penetration of systemically administered antifungal agents is critical for a proper appreciation of their antifungal efficacy in animals and humans. Both the time course of an antifungal drug and its absolute concentrations within tissues may differ significantly from those observed in the bloodstream. In addition, tissue concentrations must also be interpreted within t...
متن کاملPenetration of Candida biofilms by antifungal agents.
A filter disk assay was used to investigate the penetration of antifungal agents through biofilms containing single and mixed-species biofilms containing Candida. Fluconazole permeated all single-species Candida biofilms more rapidly than flucytosine. The rates of diffusion of either drug through biofilms of three strains of Candida albicans were similar. However, the rates of drug diffusion th...
متن کاملEffect of a novel penetration enhancer on the ungual permeation of two antifungal agents.
OBJECTIVES The aim of this study was to demonstrate the effect of a novel permeation enhancer system using two existing marketed nail lacquers and the delivery of terbinafine through human nail samples in vitro. METHODS Initially a modified Franz cell was used, where sections of human nail serve as the barrier through which drug penetrates into an agar-filled chamber infected with dermatophyt...
متن کاملAntifungal Agents
Continued advancement of medical science offers life-saving treatment options for a variety of hematologic, oncologic, and rheumatologic conditions. Immunosuppression, a common therapeutic side-effect, predisposes patients to invasive fungal infections, which are escalating in prevalence. The development of effective, welltolerated antifungals has lagged behind the advances of antibacterial the...
متن کاملAntifungal agents: Polyene, azole, antimetabolite, other and future agents
Antifungals have always been considered as one of the astonishing discoveries of the 20th century. This is correct, but the real marvel is the development of antifungal resistance in hospitals, communities, and the environment concomitant with their use. Fungal infections have emerged as an important clinical threat, with significant associated morbidity and mortality. This study is desig...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2014
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.00046-13